SYNTHESIS stems from the successful Amels 242 in our Limited Editions range. Her experienced Owner is a repeat Amels client and has customised this yacht to meet their personal requirements. SYNTHESIS features a dedicated Owners Deck with foredeck jacuzzi. There is a significant focus on blending the interior into the exterior throughout. Unique dining and entertaining layouts on multiple decks which move away from the more traditional configurations.
BOAT Design Innovation Awards 2022
Congratulations to 74-metre Amels 242 SYNTHESIS and Amels 60-metre 200 MOONSTONE, announced as finalists in the 2022 BOAT Design Innovation Awards.
Amels Limited Editions range
SYNTHESIS is an Amels 242 from our Limited Editions range. Our premium semi-custom yachts offer fast delivery with top quality proven technical platforms.
Synthesis Yacht
Synthesis yacht overview, about synthesis yacht.
Synthesis is a motor yacht with an overall length of m. The yacht's builder is Amels from The Netherlands , who launched Synthesis in 2021 . The superyacht has a beam of m , a draught of m and a volume of GT.
Synthesis features exterior design by Tim Heywood Design Ltd. and interior design by Winch Design . Up to 12 guests can be accommodated on board the superyacht, Synthesis , and she also has accommodation for 19 crew members, including the ship's captain. Synthesis has a steel hull and an aluminium superstructure. She is powered by 2 Caterpillar Inc engines , which give her a top speed of kn. The yacht carries litres of fuel on board.
In the world rankings for largest yachts, the superyacht, Synthesis , is listed at number 253 . She is the 12nd- largest yacht built by Amels . Synthesis 's owner is shown in SYT iQ and is exclusively available to subscribers. On SuperYacht Times, we have 18 photos of the yacht, Synthesis , and she is featured in 8 yacht news articles .
Synthesis is not for sale, but there are other yachts for sale in the world at the moment. It is not yet known whether or not Synthesis has a superyacht infotainment system by YachtEye .
SYNTHESIS is a 74.0 m Motor Yacht, built in Netherlands by Amels and delivered in 2021. She is one of 8 LE 242 models.
Her top speed is 16.5 kn, her cruising speed is 15.0 kn, and she boasts a maximum cruising range of 5000.0 nm at 12.5 kn, with power coming from a MTU engine. She can accommodate up to 12 guests in 6 staterooms, with 19 crew members. She has a gross tonnage of 1790.0 GT and a 12.45 m beam.
She was designed by Tim Heywood , who has designed 61 other superyachts in the BOAT Pro database.
The naval architecture was developed by Amels , who has architected 71 other superyachts in the BOAT Pro database, and the interior of the yacht was designed by Winch Design , who has 75 other superyacht interiors designed in the BOAT Pro database - she is built with a Teak deck, a Steel hull, and Aluminium superstructure.
SYNTHESIS is in the top 5% by LOA in the world. She is one of 120 motor yachts in the 70-80m size range, and, compared to similarly sized motor yachts, her cruising speed is 0.31 kn above the average, and her volume 3.32 GT above the average.
SYNTHESIS is currently sailing under the Marshall Islands flag, the 5th most popular flag state for superyachts with a total of 456 yachts registered. She is known to be an active superyacht and has most recently been spotted cruising near Italy. For more information regarding SYNTHESIS's movements, find out more about BOATPro AIS .
Specifications
Name: SYNTHESIS
Yacht Type: Motor Yacht
Yacht Subtype: Displacement
Model: LE 242
Builder: Amels
Naval Architect: Amels
Exterior Designer: Tim Heywood
Interior Designer: Winch Design
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Motor Yacht
SYNTHESIS stems from the successful Amels 242 in our Limited Editions range. Her experienced Owner is a repeat Amels client and has customised this yacht to meet their personal requirements. SYNTHESIS features a dedicated Owners Deck with foredeck jacuzzi. There is a significant focus on blending the interior into the exterior throughout. Unique dining and entertaining layouts on multiple decks which move away from the more traditional configurations.
Synthesis is a semi-custom motor yacht launched in 2020 by Amels.
AMELS are masters in the art of modern Dutch high-value yacht building. The yard is the largest superyacht facility in the Netherlands and one of the top superyacht builders in the world. In 2005 AMELS launched the successful LIMITED EDITIONS and delivered the first yacht of the series in 2007. The shipyard also specialises in the build of full-custom superyachts, with the in-construction Project Signature due to become the largest superyacht ever built in the Netherlands upon her scheduled launch in 2025.
Synthesis measures 74.00 metres in length, with a max draft of 3.85 feet and a beam of 12.45 feet. She has a gross tonnage of 1,790 tonnes.
Tim Heywood, the multi award-winning yacht designer, has produced some of the finest and largest yachts on the water. Among his exceptional designs is the stunning 133m Al Mirqab, which was awarded the coveted ‘Motor Yacht of the Year’ at the 2009 World Superyacht Awards.
Her interior design is by Winch Design.
Synthesis also features naval architecture by Damen Yachting.
Synthesis is a semi-custom Amels 242 model.
Performance and Capabilities
Synthesis has a top speed of 16.50 knots. She is powered by 2 3508b diesel engines .
She also has a range of 5,000 nautical miles.
Accommodation
Synthesis accommodates up to 12 guests . She also houses room for up to 18 crew members.
Other Specifications
Synthesis has a hull NB of 5.
Yacht Builder Amels View profile
Naval Architect Damen Yachting View profile
Exterior Designer Tim Heywood Design View profile
Interior Designer Winch Design View profile
Yacht Specs
Other amels yachts, related news.
By SuperyachtNews 06 Jan 2021
Amels and Damen Yachting deliver Synthesis
The 74m yacht is from the successful amels 242 limited editions range….
The team at Amels and Damen Yachting has marked the start of 2021 with the delivery of the Amels 242 Synthesis . The 74m Amels Limited Editions design, which features a number of layout customisations, departed the Damen Yachting Vlissingen City shipyard in the Netherlands on 4 January. Her planned itinerary is based around an extensive cruising schedule which will take the superyacht worldwide.
Synthesis stems from the successful Amels 242 Limited Editions range. Her experienced owner is a repeat Amels client and has customised this yacht to meet their personal requirements. She features a dedicated owner's deck with foredeck jacuzzi and there is a significant focus on blending the interior into the exterior throughout, with unique dining and entertaining layouts on multiple decks that move away from the more traditional configurations. There is a large aft deck swimming pool and the lower deck wellness spa continues this play on the indoor-outdoor with direct access to the swim platform for guests.
“It has been a wonderful experience to welcome back our client and to see them incorporate so many personal touches to his Amels 242,” says Rose Damen, managing director of Damen Yachting. “It is a fantastic example of what our Limited Editions concept is all about: owners being able to benefit from the existing and proven platform whilst still having the freedom to customise to meet their own specific yachting needs and still receive delivery within 12 months.”
Synthesis ’ Captain James Griffiths joined the project in spring last year, forming part of the team overseeing the build on behalf of the owner. “This has been my first new-build Amels project – the previous projects I have been involved with at the Damen Yachting shipyard have been refits,” he explains. “As always, the experience has been great and the cooperation with the shipyard, project manager and his team has gone very well. It is fantastic to see such an amazing product come together after what hasn’t been the easiest of times given the global circumstances.”
With a gross tonnage of 1,790, Synthesis accommodates 12 guests in six cabins with 19 crew. The yacht’s garage holds two nine-metre luxury tenders and the bridge deck aft features a helipad. As with all Amels Limited Editions, Synthesis benefits from the proven naval architecture by Damen Yachting. Her exterior bears the unmistakable signature of Tim Heywood and she features bespoke interiors by Winch Design. International yacht brokerage specialists Torrance Yachts advised the client and managed the build on his behalf.
Synthesis is the fifth Amels 242 to be delivered and also marks the 40th Limited Editions yacht to be delivered since 2005. Damen Yachting’s business model of upfront investment in engineering and construction, while maximising customisation and evolution, represents a good balance between full custom and semi-custom and reduces delivery time from several years to as little as a few months.
Images courtesy of Damen Yachting .
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Damen Yachting
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Amels Synthesis
About Synthesis
Contact agent.
Specifications
Yard :
Amels
Type :
Motor yacht
Guests :
12
Crew :
19
Cabins :
6
Length :
74 m / 242′10″
Beam :
12.45 m / 40′11″
Draft :
3.85 m / 12′8″
Year of build :
2021
Classification :
Lloyds
Displacement :
Full displacement
Model :
Amels 242
Type of engine :
Diesel
Brand :
Caterpillar
Model :
3516
Engine power :
2720 hp
Total power :
5440 hp
Maximum speed :
16.5 knots
Cruising speed :
12.5 knots
Range :
5000 nm
Gross tonage :
1790
Hull :
Steel
Superstructure :
Aluminium
Decking :
Teak
Interior designer :
Andrew Winch
Exterior designer :
Tim Heywood
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If you have any questions about the SYNTHESIS information page below please contact us .
74m SYNTHESIS is a limited edition luxury yacht, built in 2020 by Amels, and featuring exterior design by Tim Heywood and incredible interiors by Winch Design. This large super yacht is the epitome of luxury, with three hot tubs across her various decks, plus swimming pool and lavish Owner’s suite. She sleeps 12 guests across 6 generously proportioned cabins, and has a dedicated crew of 19.
NOTABLE FEATURES OF SYNTHESIS: ~Three on deck hot tubs ~6.5m (21 ft) swimming pool ~Dedicated Owner’s deck ~Owner’s suite with private deck and hot tub ~Full beam wellness centre with jacuzzi, sauna and gym ~Ensuite cabins
This spectacular super yacht features a raft of outdoor spaces to enjoy time with friends and family. On the main deck, the standout feature is the well-proportioned swimming pool. The pool is 6.7m long, 3.4m wide, 1.25m deep and comes complete with counter-current jets for ‘lap’ swimming. The surrounding space is filled with a variety of couches, sun loungers and convenient coffee tables, making this the ideal spot to relax in the sun.
The swimming platform below offers easy access to the sea and water toys.
Above on the middle deck is the main outdoors dining area. This space is sheltered by the deck overhand above, providing guests with a comfortable place for al fresco dining.
The spacious upper deck above features a hot tub, with a variety of couches, loungers and tables. A to port stairwell leads to the top level, where another hot tub is positioned, surrounded by sun pads for soaking up the sun. This area’s elevated position provides incredible views of the surrounding area.
Amidships on the main deck is shipyard Amel’s award-winning, 75 square-metre wellness centre. This incredible centre can be configured to include a variety of wellness and relaxation options, including jacuzzi, hammam, sauna with outside window, gym, massage or beauty, shower and day head, inboard wet space, fully drained, with a sofa and juice bar. The wellness centre also features a unique, foldable sea terrace. This terrace folds down on the starboard side of the vessel, providing yet another outdoors enjoyment area as well as direct access to the ocean. There is also an external stairwell to connect the sea terrace to the main deck and swimming pool.
As well as the wellness centre, the main deck also features beautiful living and dining areas, with glass windbreakers ensuring uninterrupted ocean views
Above the main deck is the dedicated Owner’s Deck. This deck holds the incredible Owner’s suite forward, an amidships office and lounge area, which connects to the aft deck dining space.
SYNTHESIS Specifications
Type/Year:
Amels/2022
Refit:
Beam:
12.45m (40'10")
L.O.A.:
74.0m (242'9")
Crew:
19
Guests:
12
Max Speed:
16.5 knots
Cabins:
6
Engines:
Cruise Speed:
14 knots
More Yacht Info:
, , ,
Builder/Designer:
, , , ,
Locations:
She can reach a top speed of 16.5 knots and has a nautical range of 5,000 miles at 12.5 knots.
Yacht Accommodation
The accommodation is for 12 guests across 6 cabins, which consist of: 1 Owner’s suite, 2 VIP cabins, and 3 double cabins which can be configured as either double or twins. The luxurious Owner’s suite resides forward of the dedicated Owner’s deck. From this forward-facing stateroom, port and starboard doors lead to the secluded Owner’s deck, which features a jacuzzi and sunbeds. This private area is invisible to the wheelhouse above, providing guests with an ideal spot for restful moments of privacy. Inside, the suite features a king-sized bed, his and hers ensuites and dressing area, and tasteful décor throughout. Amidships is an office area and lounge, which connect to the aft deck and dining area. Below on the main deck are two generously sized VIP cabins, and on the lower deck are the remaining 3 cabins. An experienced crew of 19 will provide guests with a five star experience.
Amenities and Extras
Synthesis disclaimer:.
The luxury yacht SYNTHESIS displayed on this page is merely informational and she is not necessarily available for yacht charter or for sale, nor is she represented or marketed in anyway by CharterWorld. This web page and the superyacht information contained herein is not contractual. All yacht specifications and informations are displayed in good faith but CharterWorld does not warrant or assume any legal liability or responsibility for the current accuracy, completeness, validity, or usefulness of any superyacht information and/or images displayed. All boat information is subject to change without prior notice and may not be current.
Quick Enquiry
"Since yacht design is highly competitive, you could be forgiven for thinking that there might be some animosity between designers. But that notion is far from reality. I am blessed with being able to count on some of the world’s leading designers as close friends, among them Tim Heywood, with whom we have collaborated on various large motor yacht projects, including the award winners Pelorus, Ice and Kogo." - "Creatively, Tim is afraid of nothing and will often conceptualise ideas that bewilder shipyards." - Terence Disdale speaking of Tim Heywood, the designer of this yacht.
74m CRN 131 | From US$ 870,000/wk
LEANDER G | From EUR€ 385,000/wk
LADY E | From US$ 665,000/wk
2021 Amels 243ft / 74m
SYNTHESIS Yacht Charter
SYNTHESIS is actively available for charter in several cruising destinations.
The luxury motor yacht SYNTHESIS was built by Amels and delivered to her owner in 2021.
The exterior of SYNTHESIS is designed by Tim Heywood Design.
Charter guest accommodation
SYNTHESIS has been designed to comfortably accommodate up to 12 charter guests in 6 suites.
The guest cabins comprise a primary suite with a king size bed and en-suite bathroom facilities, a cabin with a king size bed and en-suite bathroom facilities and 4 cabins with a double bed and en-suite bathroom facilities.
Your luxury charter crew
Your luxury charter on board motor yacht SYNTHESIS will be managed by the crew of 20 including the captain.
The crew will ensure you have a relaxed and enjoyable charter experience with all of your needs catered for while on board.
The 20 crew have their own separate crew quarters allowing guests to enjoy increased levels of privacy.
Amenities & Entertainment
Amenities on board for the charter guests include Air Conditioning, Cinema, Elevator, Exercise equipment, Gym, Helipad, Indoor audio system, Jacuzzi on deck, Outdoor audio system, Sauna, Spa, Sun pads, Sun loungers, Swimming pool, TV outdoor and TV saloon.
An extensive list of further amenities and water toys can be seen under the features and amenities section.
Yacht charter destinations
SYNTHESIS is Currently cruising in the Caribbean, the East Mediterranean and the West Mediterranean.
Sample itineraries for the cruising destinations can be supplied by your professional charter broker allowing you to plan your luxury yacht charter vacation in detail.
Windward Islands
Leeward Islands
Cayman Islands
Trinidad & Tobago
Turks Caicos
Greater Antilles
Leeward Antilles
East Mediterranean
Middle East
North East Africa
West Mediterranean
Balearic Islands
Corsica & Sardinia
Sicily & Aeolian Islands
Amalfi Coast
French Riviera
South of France
North Africa
Air Conditioning
Movie Theatre
Exercise equipment
Indoor audio system
Jacuzzi on deck
Outdoor audio system
Sun loungers
Swimming pool
Inflatable Watertoys
1x 8.6m Pascoe Beachlander Tender
1x 9.2m Meyer Limo Tender
Destinations
Frequently Asked Questions
How much to charter synthesis.
SYNTHESIS has a weekly charter price starting at €800,000 and an estimated daily charter price of €133,000.
How many guests on board SYNTHESIS?
SYNTHESIS can accommodate 12 sleeping guests on board in 6 cabins.
Legal Disclaimer
Motor Yacht SYNTHESIS is displayed on this page for informational purposes and may not necessarily be available for charter. The yacht details are displayed in good faith and whilst believed to be correct are not guaranteed, please check with your charter broker. Charter Index does not warrant or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information or images displayed as they may not be current. All yacht details and charter pricing are subject to change without prior notice and are without warranty.
U.S. Customs & Border Protection
The yachting industry has no global listing service to which all charter yachts must subscribe to, making it impossible to ascertain a truly up-to-date view of the market. Charter Index is a news and information service and not always informed when yachts leave the charter market, or when they are recently sold and renamed, it is not always clear if they are still for charter. Whilst we endeavour to maintain accurate information, the existence of a listing on Charter Index should in no way supersede official documentation supplied by the representatives of a yacht.
Specification
Yacht name
SYNTHESIS
Speed (cruising)
27.8kph / 15kn
Speed (max)
30.6kph / 16.5kn
Hull
Monohull
Launched
2021
Builder
Amels
Designer
Tim Heywood Design
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SYNTHESIS Yacht – Stunning $100 Million Superyacht
The yacht is an Amels 242 model and was delivered from the shipyard in 2021 featuring interior design by Winch Design.
The exterior is designed by Tim Heywood Design. The yacht is the epitome of luxury, and features multiple elements that make her the ultimate wellness centre on the water.
Synthesis
74 metres
12
19
Amels
Tim Heywood
Tim Heywood
2021
17 knots
Caterpillar
1,790 ton
SYNTHESIS yacht interior
The interior of the SYNTHESIS yacht is designed by Winch Design , a British design house. The yacht has accommodation for 12 guests in 6 cabins. The configuration of the suites is 1 master suite, 2 VIP rooms, and 3 doubles.
There is accommodation for 19 crews. The yacht is all about luxury in combination with wellness.
The award-winning ship has a Jacuzzi, hammam, and sauna with an outside window to watch the views outside the yacht, and a massage or a beauty room.
The Jacuzzi area is surrounded by sun pads and is elevated so guests can enjoy the sea views.
There is also a juice bar onboard. The yacht has wonderful living and dining spaces with glass windbreakers for uninterrupted views of the ocean views.
The ship features a unique foldable sea terrace that folds down from the starboard side. The beach club offers an indoor/outdoor area for guests to enjoy. The guests can jump right into the ocean from the swimming platform.
There is also an external stairwell that connects the sea terrace to the main deck and the swimming pool. The swimming pool is surrounded by coffee tables and seating for guests to enjoy.
The swimming pool also features a counter-current jet so guests can swim laps in the 6.7m pool. The garage is filled with water toys and tenders for guests to enjoy the water below.
The exterior of the SYNTHESIS yacht features a design from Tim Heywood Design . She is an Amels 242 model and was delivered from the Amels shipyard in 2021.
She features underwater lights and a string exterior with a white steel hull and aluminum superstructure and teak decks. She underwent a refit in 2021 as well.
Specifications
The SYNTHESIS yacht has a length of 74m, and a beam of 12.46m with a draft of 3.85m. She has a cruising speed of 14 knots, and a maximum speed of 17 knots thanks to her twin Caterpillar engine.
She has a displacement of 1790 gross tons and a range of 5000 nautical miles. She was built to a Lloyd’s Register classification society rules.
The $100 million yacht has an annual running cost of $5 – $10 million.
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Yacht, IMO 9794587
VesselFinder
Miscellaneous
The current position of SYNTHESIS is at West Mediterranean reported 5 mins ago by AIS. The vessel is en route to CALA DI VOLPE , and expected to arrive there on Sep 19, 20:00 . The vessel SYNTHESIS (IMO 9794587, MMSI 538071810) is a Yacht built in 2021 (3 years old) and currently sailing under the flag of Marshall Islands .
Voyage Data
Predicted ETA
-
Distance / Time
-
Course / Speed
Current draught
3.9 m
Navigation Status
Under way
Position received
IMO / MMSI
9794587 / 538071810
Callsign
V7A5646
Flag
Marshall Islands
Length / Beam
74 / 12 m
Ship position & weather
Recent port calls, vessel particulars.
IMO number
9794587
Vessel Name
SYNTHESIS
Ship Type
Yacht
Flag
Marshall Islands
Year of Build
2021
Length Overall
74.00
Length BP
Beam
11.94
Draught
-
Depth
-
Gross Tonnage
1790
Net Tonnage
-
Deadweight
TEU
-
Crude Oil
-
Gas )
-
Grain )
-
Bale )
-
Ballast Water )
-
Fresh Water )
-
Builder
Place of Build
Hull
-
Material
-
Engine Builder
-
Engine Type
-
Engine Power
-
Fuel Type
-
Service Speed
-
Propeller
-
Registered Owner
-
Address
-
Website
-
Email
-
Address
-
Website
-
Email
-
ISM Manager
-
Address
-
Website
-
Email
-
P&I Club
-
Classification Society
SYNTHESIS current position and history of port calls are received by AIS. Technical specifications, tonnages and management details are derived from VesselFinder database. The data is for informational purposes only and VesselFinder is not responsible for the accuracy and reliability of SYNTHESIS data.
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Synthesis 66
Amenities & Toys
Rates & Regions
+ Shortlist
SYNTHESIS 66 YACHT CHARTER
41.81m / 137'2 feadship 1982 / 2023.
Previous Yacht
Cabin Configuration
2 Double/Twin
Special Features:
Full-beam master cabin for superior comfort
Impressive 3,500nm range
Recent refit in 2023
Sleeps 10 guests
NuovaJolly RIB
Luxury charter yacht 'Synthesis 66' is the prime candidate for anyone looking for a taste of the superyacht lifestyle
The 41.8m/137'2" motor yacht 'Synthesis 66' by the Dutch shipyard Feadship offers flexible accommodation for up to 10 guests in 5 cabins and features interior styling by Larvor.
Built in 1982, Synthesis 66 offers beautifully proportioned decks for exquisite indoor/outdoor living during a luxury yacht charter .
Guest Accommodation
Synthesis 66 offers guest accommodation for up to 10 guests in 5 suites comprising a master suite located on the main deck, one VIP cabin, one twin cabin and two cabins that can operate as twins or doubles. She is also capable of carrying up to 8 crew onboard to ensure a relaxed luxury yacht charter experience.
Onboard Comfort & Entertainment
Keeping comfortable and entertained on Synthesis 66 is easy thanks to the available amenities, particularly a deck jacuzzi, perfect to enjoy the scenery with your favourite drink in hand.
Whatever your activities on your charter, you'll find some impressive features are seamlessly integrated to help you, particularly Wi-Fi connectivity, allowing you to stay connected at all times, should you wish. Guests will experience complete comfort while chartering thanks to air conditioning.
Performance & Range
Built with a steel hull and aluminium superstructure, she offers greater on-board space and is more stable when at anchor thanks to her full-displacement hull. Powered by twin Caterpillar engines, she comfortably cruises at 12 knots, reaches a maximum speed of 13 knots with a range of up to 3,500 nautical miles from her 44,000 litre fuel tanks at cruising speed.
Set against the backdrop of your chosen cruising ground, you and your guests can enjoy fun on the water with the collection of water toys and accessories aboard Synthesis 66. Guests can feel the wind in their hair and jump the waves on one of the two Yamaha FX WaveRunners. Additionally, there are three SEABOBs, offering a truly remarkable experience that lets you skim along the surface or swim with the fishes quietly and safely. In addition there are two O'Neil wakeboards so guests can show off at speed. If that isn't enough Synthesis 66 also features fishing equipment and snorkelling equipment. When it comes to Tenders, Synthesis 66 has you covered - with two tenders, including a NuovaJolly RIB.
Based in the magical waters of the Mediterranean all year round Synthesis 66 is ready for your next luxury yacht charter. Let Synthesis 66 Discover the magical places, food and experiences of the the Mediterranean.
Luxury motor yacht Synthesis 66 is one of a kind, offering world-class onboard amenities coupled with an overflowing toy box full of the latest water sports gear for unforgettable yacht charters wherever you are.
TESTIMONIALS
There are currently no testimonials for Synthesis 66, please provide .
Synthesis 66 Photos
Length
41.81m / 137'2
Beam
7.9m / 25'11
Draft
2.5m / 8'2
Gross Tonnage
347 GT
Cruising Speed
12 Knots
Built
| (Refitted)
Builder
Feadship
Model
Custom
Exterior Designer
De Voogt
Interior Design
Larvor
Amenities & Entertainment
For your relaxation and entertainment Synthesis 66 has the following facilities, for more details please speak to your yacht charter broker.
Synthesis 66 is reported to be available to Charter with the following recreation facilities:
1 x NuovaJolly Prince 38 RIB with 2 x Yamaha 300 HP engines
1 x 3.4m / 11'2 Zodiac Tender Yamaha 25 HP engine
For a full list of all available amenities & entertainment facilities, or price to hire additional equipment please contact your broker.
+ shortlist
For a full list of all available amenities & entertainment facilities, or price to hire additional equipment please contact your broker.
'Synthesis 66' Charter Rates & Destinations
Summer Season
May - September
€150,000 p/week + expenses Approx $161,000
High Season
€170,000 p/week + expenses Approx $182,000
Cruising Regions
Mediterranean France, Italy, Monaco
HOT SPOTS: Amalfi Coast, Corsica, French Riviera, Ibiza, Sardinia, The Balearics
Winter Season
October - April
Mediterranean France, Monaco
HOT SPOTS: Corsica, French Riviera
Note: Not for charter to U.S. residents while in U.S. waters
Charter Synthesis 66
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Timmerman Yachts is a Russian builder of quality luxury motor yachts. Based in Moscow, it is owned by a group of Dutch and Russian investors and operates out of Moscow Shipyard. Several noted naval architecture and yacht design firms are involved with Timmerman, including Vripack, Guido de Groot Design, Ginton Naval Architects, Jon Bannenberg Ltd., and Francis Design Ltd.
Founded in 2003, the company was named for 17th century Dutch boat builder Franz Timmerman who brought Dutch boat manufacturing techniques to Russia and co-founded the Russian navy. Timmerman Yachts has more than 1,000 employees working at the Moscow Shipyard.
Timmerman has delivered a number of semi-custom luxury yachts between 26-47 metres in length, including TM26 and Timmerman FD-51, designed by Francis Design Ltd. Other notable Timmerman yachts include Victoria M, Alexandra (now Latitude) and Olsten 125′.
One of the 10 largest yacht builders in the world, Timmerman is focused on building high-quality luxury yachts at more competitive prices. Its Russian-Dutch partnership provides great yacht-building capabilities. Timmerman builds yacht to the highest standards and holds DNV, MCA and Russian River Register certification. The company reportedly has more than a dozen yachts in some phase of construction.
Bioorganic chemistry dept., School of biology, Moscow State University. Magister degree in biochemistry, diploma with honors.
Photobiochemistry dept., A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University. Post-graduate student, PhD project.
1999
PhD degree. Thesis title: Investigation of proton transport and ATP synthesis coupling mechanism of ATP synthase from purple bacterium .
A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University. Joint Russian-German project on investigating the role of chloride in bioenergetics of alkalophyllic halophyllic bacteria. Supervisor - Prof. V. P. Skulachev. Supported by INTAS grant N 93-742-Extension.
Division of Biophysics, Dept. of Biology, University of Osnabrück (Germany) in collaboration with Dept. of Bioenergetics, A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University. Joint Russian-German project on proteins involved in transmembrane proton translocation supported by Deutsche Forschungsgemeinschaft grant DFG-RUS-436 . Supervisors: Prof. W. Junge and Dr. A. Mulkidjanian.
Short-term EMBO Fellowship, Laboratory of Molecular Biophysics, Oxford University (UK). Molecular dynamics simulations of Na -ATP synthase -subunit. Supervisor - Prof. M.S.P. Sansom.
Short visit to the group of Prof. B.A. Melandri, Dept. of Biology, University of Bologna (Italy). Introduction of single aminoacid mutations in ATP synthase of .
Alexander von Humboldt Research Fellow at the Division of Biophysics, Dept. of Biology, University of Osnabrück (Germany). Project on the investigation of ATP synthase coupling mechanism.
Postdoc, ATP Systems Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST) at Tokyo Institute of Technology (Japan). Investigation of subunit epsilon regulatory role in PS3 ATP synthase.
Postdoc at Chemical Resources Lab, Tokyo Institute of Technology (Japan). Investigaiton of the regulatory mechanisms in PS3 ATP synthase.
Postdoc, Japan Science and Technology Agency (JST) ICORP ATP Synthesis Regulation Project (Japan). Investigation of MgADP-inhibition in bacterial ATP synthase.
Associate professor, School of Bioengineering and Bioinformatics, Lomonosov Moscow State University (Russia).
1. Suzuki T, Wakabayashi C, Tanaka K, Feniouk BA, Yoshida M. (2011): Modulation of Nucleotide Specificity of Thermophilic F O F 1 -ATP Synthase by epsilon-Subunit. J Biol Chem. 286 , pp.16807-16813.
2. Saita E, Iino R, Suzuki T, Feniouk BA, Kinosita K Jr, Yoshida M. (2010): Activation and stiffness of the inhibited states of F 1 -ATPase probed by single-molecule manipulation. J Biol Chem. 285 , pp.11411-11417.
3. Feniouk BA, Kato-Yamada Y, Yoshida M, Suzuki T. (2010): Conformational transitions of subunit epsilon in ATP synthase from thermophilic Bacillus PS3. Biophys J. 98 , pp.434-442.
4. Feniouk , B.A., and Junge, W. (2009) : Proton translocation and ATP synthesis by the F 0 F 1 -ATPase of purple bacteria. In: The Purple Phototrophic Bacteria C. Hunter, N., Daldal, F., Thurnauer, M.C., and Beatty, J.T. (eds). Dordrecht : Springer, pp.475493.
5. Feniouk B.A., and Yoshida M. (2008): Regulatory Mechanisms of Proton-Translocating F O F 1 -ATP Synthase. Results Probl. Cell. Differ. 45 , pp.279-308.
6. Suzuki T., Ozaki Y., Sone N., Feniouk B.A., and Yoshida M. (2007): The product of uncI gene in F 1 F O -ATP synthase operon plays a chaperone-like role to assist c -ring assembly. Proc Natl Acad Sci U S A. 104 , pp.20776-20781.
7. Feniouk B.A., Rebecchi A., Giovannini D., Anefors S., Mulkidjanian A.Y., Junge W., Turina P., Melandri B.A. (2007): Met23Lys mutation in subunit gamma of F O F 1 -ATP synthase from Rhodobacter capsulatus impairs the activation of ATP hydrolysis by protonmotive force. Biophys. et Biochim. Acta, 1767 , pp.1319-1330.
8. Feniouk B.A., Suzuki T., and Yoshida M. (2007): Regulatory interplay between proton motive force, ADP, phosphate, and subunit epsilon in bacterial ATP synthase. J. Biol. Chem., 282 , pp.764-772.
9. Feniouk B.A., Suzuki T., and Yoshida M. (2006): The role of subunit epsilon in the catalysis and regulation of F O F 1 -ATP synthase. Biophys. et Biochim. Acta, 1757 , pp.326-338.
10. Feniouk BA, Junge W. (2005): Regulation of the F0F1-ATP synthase: the conformation of subunit epsilon might be determined by directionality of subunit gamma rotation. FEBS Lett. 579 , pp.5114-5118
11. B. A. Feniouk , A. Y. Mulkidjanian, and W. Junge. (2005): Proton slip in the ATP synthase of Rhodobacter capsulatus : induction, proton conduction and nucleotide dependence. Biophys. et Biochim. Acta, 1706 , pp. 184-194
12. B. A. Feniouk , M. A. Kozlova, D. A. Knorre, D. A. Cherepanov, A. Y. Mulkidjanian, and W. Junge. (2004): The proton driven rotor of ATP synthase: Ohmic conductance (10 fS), and absence of voltage gating. Biophys. J. 86 , pp.4094-4109
13. D.A. Cherepanov, B.A. Feniouk , W. Junge, A.Y. Mulkidjanian. (2003) Low dielectric permittivity of water at the membrane interface: effect on the energy coupling mechanism in biological membranes. Biophys. J. 85 , pp. 1307-16.
14. B. A. Feniouk , D. Cherepanov, Voskoboinikova N.E., A. Y. Mulkidjanian, and W. Junge. (2002): Chromatophore Vesicles of Rhodobacter capsulatus Contain on Average One F O F 1 -ATP Synthase Each. Biophys. J. 82 , pp.1115-22.
15. Boris A. Feniouk , Dmitry A. Cherepanov, Wolfgang Junge and Armen Y. Mulkidjanian (2001): Coupling of proton flow to ATP synthesis in Rhodobacter capsulatus : F 0 F 1 -ATP synthase is absent from about half of chromatophores. Biophys. et Biochim. Acta, 1506 , pp.189-203.
16. Feniouk , B. A., Cherepanov, D. A., Junge, W., Mulkidjanian, A. Y. (1999): ATP synthase of Rhodobacter capsulatus : coupling of proton flow through F O to reactions in F 1 under the ATP synthesis and slip conditions. FEBS Lett. 445 , pp.409-14.
17. Feniouk , B. A., Junge, W., Mulkidjanian, A. Y. (1998): ATP-synthase of Rhodobacter capsulatus : proton flow and ATP synthesis in response to light flashes. In: Photosynthesis: Mechanisms and Effects, Ed. G. Garab (Kluver Academic Publishers, Dordrecht ), pp.1679-1682.
18. Gopta O. A., Feniouk B. A., Junge W., Mulkidjanian A. Y. (1998): The cytochrome bc1 complex of Rhodobacter capsulatus : ubiquinol oxidation in a dimeric Q-cycle? FEBS Lett. 431 , pp.291-296
SYNTHESIS Yacht • Mark Scheinberg $100M Superyacht
The yacht Synthesis was built by Amels Yachts and was delivered to her owner in 2021.The yacht is designed by Tim Heywood.Synthesis is a sistership of Sixth Sense and New Secret.. Specifications. The yacht is powered by Caterpillar engines.Her top speed is 17 knots. Her cruising speed is 12 knots. Her range is more than 4,500nm.
Amels
SYNTHESIS stems from the successful Amels 242 in our Limited Editions range. Her experienced Owner is a repeat Amels client and has customised this yacht to meet their personal requirements. SYNTHESIS features a dedicated Owners Deck with foredeck jacuzzi. There is a significant focus on blending the interior into the exterior throughout.
Synthesis Yacht
Synthesis is a motor yacht with an overall length of m. The yacht's builder is Amels from The Netherlands, who launched Synthesis in 2021. The superyacht has a beam of m, a draught of m and a volume of . GT.. Synthesis features exterior design by Tim Heywood Design Ltd. and interior design by Winch Design. Up to 12 guests can be accommodated on board the superyacht, Synthesis, and she also has ...
SYNTHESIS yacht (Amels, 74m, 2021)
SYNTHESIS is a 74.0 m Motor Yacht, built in Netherlands by Amels and delivered in 2021. She is one of 8 LE 242 models. Her top speed is 16.5 kn, her cruising speed is 15.0 kn, and she boasts a maximum cruising range of 5000.0 nm at 12.5 kn, with power coming from a MTU engine.
SYNTHESIS Yacht
The award winning 73.99m/242'9" motor yacht 'Synthesis' was built by Amels in the Netherlands. Her interior is styled by British designer design house Winch Design and she was delivered to her owner in January 2021. This luxury vessel's exterior design is the work of Tim Heywood Design.
74.0m Synthesis Superyacht
Synthesis is a semi-custom motor yacht launched in 2020 by Amels. AMELS are masters in the art of modern Dutch high-value yacht building. The yard is the largest superyacht facility in the Netherlands and one of the top superyacht builders in the world. In 2005 AMELS launched the successful LIMITED EDITIONS and delivered the first yacht of the ...
Amels and Damen Yachting deliver Synthesis
Synthesis is the fifth Amels 242 to be delivered and also marks the 40th Limited Editions yacht to be delivered since 2005. Damen Yachting's business model of upfront investment in engineering and construction, while maximising customisation and evolution, represents a good balance between full custom and semi-custom and reduces delivery time ...
Motor yacht Amels Synthesis 74 length metres The shipyard Amels rolled off the slipway 2021 in year. The yacht can accommodate up to 12 guests and is maintained and operated by 19 crew members. The interior designer was Winch Design. The in-house design division of the shipyard was responsible for her appearance.
Motor yacht Synthesis
Synthesis is a 74 m / 242′10″ luxury motor yacht. She was built by Amels in 2021. With a beam of 12.45 m and a draft of 3.85 m, she has a steel hull and aluminium superstructure. This adds up to a gross tonnage of 1790 tons. She is powered by Caterpillar engines of 2720 hp each giving her a maximum speed of 16.5 knots and a cruising speed of 12.5 knots. Synthesis's maximum range is ...
PDF SYN T H ES IS
tion on boardDelivered in 2021, SYNTHESIS was built to highest standards by the Amels yard in the Netherlands to the designs of the renowned design houses Tim Heywood (exterior) and Winch Desi. n (interior). She was the winner of the prestigious "Best Interior Design, Motor Yachts 500GT and above" at the 2022 Boat International Design & Inno.
Yacht SYNTHESIS, Amels
74m SYNTHESIS is a limited edition luxury yacht, built in 2020 by Amels, and featuring exterior design by Tim Heywood and incredible interiors by Winch Design. This large super yacht is the epitome of luxury, with three hot tubs across her various decks, plus swimming pool and lavish Owner's suite. She sleeps 12 guests across 6 generously ...
SYNTHESIS Yacht Charter
SYNTHESIS is actively available for charter in several cruising destinations. The luxury motor yacht SYNTHESIS was built by Amels and delivered to her owner in 2021. The exterior of SYNTHESIS is designed by Tim Heywood Design. Charter guest accommodation. SYNTHESIS has been designed to comfortably accommodate up to 12 charter guests in 6 suites.
Amels delivers 74m superyacht SYNTHESIS
By Katia Damborsky 5 January 2021. Marking the first major delivery of 2021, the 74m (249ft) motor yacht SYNTHESIS has departed Amels' facilities in Vlissingen on her maiden voyage towards Gibraltar and will be cruising in the Mediterranean. Hitting the water for the first time in April 2020, SYNTHESIS has now been handed over to her Owners ...
SYNTHESIS Yacht
SYNTHESIS Yacht - Stunning $100 Million Superyacht. The yacht is an Amels 242 model and was delivered from the shipyard in 2021 featuring interior design by Winch Design. The exterior is designed by Tim Heywood Design. The yacht is the epitome of luxury, and features multiple elements that make her the ultimate wellness centre on the water.
MARK SCHEINBERG • Net Worth $5 Billion • House
The yacht Synthesis was built by Amels Yachts and was delivered to her owner in 2021. The yacht is designed by Tim Heywood. Synthesis is a sistership of Sixth Sense and New Secret. The yacht is powered by Caterpillar engines. Her top speed is 17 knots. Her cruising speed is 12 knots. Her range is more than 4,500nm.
SYNTHESIS Yacht Features
Built by the luxury yacht builder- Amels, the yacht encompasses exterior furniture and decorations that radiate contemporary elegance. Synthesis's outdoor spaces are adorned with chic furnishings details and tasteful decor, creating the perfect ambiance for alfresco dining, lounging, and enjoying the sea breeze on the deck jacuzzi.
SYNTHESIS Yacht for Charter
SYNTHESIS CHARTER YACHT. Amels in the Netherlands created the award-winning 74m/242'9″ motor yacht 'Synthesis.'. Her interior was designed by the British design firm Winch Design, and she was delivered to her owner in January 2021. Tim Heywood Design created the outside design for this premium watercraft.
SYNTHESIS, Yacht
The current position of SYNTHESIS is at West Mediterranean reported 3 mins ago by AIS. The vessel SYNTHESIS (IMO 9794587, MMSI 538071810) is a Yacht built in 2021 (3 years old) and currently sailing under the flag of Marshall Islands . Plans & Prices. Track on Map Add Photo. Add to fleet.
Synthesis 66 Yacht Charter
Synthesis 66 is a distinctly sophisticated superyacht promising unforgettable luxury yacht charters. The 41.8m/137'2" 'Synthesis 66' motor yacht built by the Dutch shipyard Feadship is available for charter for up to 10 guests in 5 cabins. This yacht features interior styling by Larvor. Built in 1982, Synthesis 66 offers beautifully ...
Timmerman
Timmerman. Timmerman Yachts is a Russian builder of quality luxury motor yachts. Based in Moscow, it is owned by a group of Dutch and Russian investors and operates out of Moscow Shipyard. Several noted naval architecture and yacht design firms are involved with Timmerman, including Vripack, Guido de Groot Design, Ginton Naval Architects, Jon ...
VALERIE SUBBOTIN • Net Worth $100 Million • House • Yacht
He is the owner of the Heesen yacht GALVAS.. The GALVAS yacht, built in 2019, is a luxurious creation of Heesen Yachts, boasting an intricate design by H2 Yacht Design.. Powered by robust MTU engines, the yacht cruises comfortably at 12 knots with a maximum speed of 16 knots, offering a range exceeding 3000 nautical miles. The yacht's luxurious interior accommodates 12 guests, and a crew of ...
Ost Power 20 GRP Sport Fisherman or general purpose boat
This design was commissioned by Russian builder Ost Yachts, based in Moscow. Their brief was for a boat with modern stealth-type styling and with potential for multiple usage formats. The version shown here is the first to be introduced and is suitable for use as a sportfisherman, diveboat or patrol boat.
Boris Feniouk: CV
List of Publications. 1. Suzuki T, Wakabayashi C, Tanaka K, Feniouk BA, Yoshida M. (2011): Modulation of Nucleotide Specificity of Thermophilic F O F 1-ATP Synthase by epsilon-Subunit. J Biol Chem. 286, pp.16807-16813. 2. Saita E, Iino R, Suzuki T, Feniouk BA, Kinosita K Jr, Yoshida M. (2010): Activation and stiffness of the inhibited states of F 1-ATPase probed by single-molecule manipulation.
COMMENTS
The yacht Synthesis was built by Amels Yachts and was delivered to her owner in 2021.The yacht is designed by Tim Heywood.Synthesis is a sistership of Sixth Sense and New Secret.. Specifications. The yacht is powered by Caterpillar engines.Her top speed is 17 knots. Her cruising speed is 12 knots. Her range is more than 4,500nm.
SYNTHESIS stems from the successful Amels 242 in our Limited Editions range. Her experienced Owner is a repeat Amels client and has customised this yacht to meet their personal requirements. SYNTHESIS features a dedicated Owners Deck with foredeck jacuzzi. There is a significant focus on blending the interior into the exterior throughout.
Synthesis is a motor yacht with an overall length of m. The yacht's builder is Amels from The Netherlands, who launched Synthesis in 2021. The superyacht has a beam of m, a draught of m and a volume of . GT.. Synthesis features exterior design by Tim Heywood Design Ltd. and interior design by Winch Design. Up to 12 guests can be accommodated on board the superyacht, Synthesis, and she also has ...
SYNTHESIS is a 74.0 m Motor Yacht, built in Netherlands by Amels and delivered in 2021. She is one of 8 LE 242 models. Her top speed is 16.5 kn, her cruising speed is 15.0 kn, and she boasts a maximum cruising range of 5000.0 nm at 12.5 kn, with power coming from a MTU engine.
The award winning 73.99m/242'9" motor yacht 'Synthesis' was built by Amels in the Netherlands. Her interior is styled by British designer design house Winch Design and she was delivered to her owner in January 2021. This luxury vessel's exterior design is the work of Tim Heywood Design.
Synthesis is a semi-custom motor yacht launched in 2020 by Amels. AMELS are masters in the art of modern Dutch high-value yacht building. The yard is the largest superyacht facility in the Netherlands and one of the top superyacht builders in the world. In 2005 AMELS launched the successful LIMITED EDITIONS and delivered the first yacht of the ...
Synthesis is the fifth Amels 242 to be delivered and also marks the 40th Limited Editions yacht to be delivered since 2005. Damen Yachting's business model of upfront investment in engineering and construction, while maximising customisation and evolution, represents a good balance between full custom and semi-custom and reduces delivery time ...
Motor yacht Amels Synthesis 74 length metres The shipyard Amels rolled off the slipway 2021 in year. The yacht can accommodate up to 12 guests and is maintained and operated by 19 crew members. The interior designer was Winch Design. The in-house design division of the shipyard was responsible for her appearance.
Synthesis is a 74 m / 242′10″ luxury motor yacht. She was built by Amels in 2021. With a beam of 12.45 m and a draft of 3.85 m, she has a steel hull and aluminium superstructure. This adds up to a gross tonnage of 1790 tons. She is powered by Caterpillar engines of 2720 hp each giving her a maximum speed of 16.5 knots and a cruising speed of 12.5 knots. Synthesis's maximum range is ...
tion on boardDelivered in 2021, SYNTHESIS was built to highest standards by the Amels yard in the Netherlands to the designs of the renowned design houses Tim Heywood (exterior) and Winch Desi. n (interior). She was the winner of the prestigious "Best Interior Design, Motor Yachts 500GT and above" at the 2022 Boat International Design & Inno.
74m SYNTHESIS is a limited edition luxury yacht, built in 2020 by Amels, and featuring exterior design by Tim Heywood and incredible interiors by Winch Design. This large super yacht is the epitome of luxury, with three hot tubs across her various decks, plus swimming pool and lavish Owner's suite. She sleeps 12 guests across 6 generously ...
SYNTHESIS is actively available for charter in several cruising destinations. The luxury motor yacht SYNTHESIS was built by Amels and delivered to her owner in 2021. The exterior of SYNTHESIS is designed by Tim Heywood Design. Charter guest accommodation. SYNTHESIS has been designed to comfortably accommodate up to 12 charter guests in 6 suites.
By Katia Damborsky 5 January 2021. Marking the first major delivery of 2021, the 74m (249ft) motor yacht SYNTHESIS has departed Amels' facilities in Vlissingen on her maiden voyage towards Gibraltar and will be cruising in the Mediterranean. Hitting the water for the first time in April 2020, SYNTHESIS has now been handed over to her Owners ...
SYNTHESIS Yacht - Stunning $100 Million Superyacht. The yacht is an Amels 242 model and was delivered from the shipyard in 2021 featuring interior design by Winch Design. The exterior is designed by Tim Heywood Design. The yacht is the epitome of luxury, and features multiple elements that make her the ultimate wellness centre on the water.
The yacht Synthesis was built by Amels Yachts and was delivered to her owner in 2021. The yacht is designed by Tim Heywood. Synthesis is a sistership of Sixth Sense and New Secret. The yacht is powered by Caterpillar engines. Her top speed is 17 knots. Her cruising speed is 12 knots. Her range is more than 4,500nm.
Built by the luxury yacht builder- Amels, the yacht encompasses exterior furniture and decorations that radiate contemporary elegance. Synthesis's outdoor spaces are adorned with chic furnishings details and tasteful decor, creating the perfect ambiance for alfresco dining, lounging, and enjoying the sea breeze on the deck jacuzzi.
SYNTHESIS CHARTER YACHT. Amels in the Netherlands created the award-winning 74m/242'9″ motor yacht 'Synthesis.'. Her interior was designed by the British design firm Winch Design, and she was delivered to her owner in January 2021. Tim Heywood Design created the outside design for this premium watercraft.
The current position of SYNTHESIS is at West Mediterranean reported 3 mins ago by AIS. The vessel SYNTHESIS (IMO 9794587, MMSI 538071810) is a Yacht built in 2021 (3 years old) and currently sailing under the flag of Marshall Islands . Plans & Prices. Track on Map Add Photo. Add to fleet.
Synthesis 66 is a distinctly sophisticated superyacht promising unforgettable luxury yacht charters. The 41.8m/137'2" 'Synthesis 66' motor yacht built by the Dutch shipyard Feadship is available for charter for up to 10 guests in 5 cabins. This yacht features interior styling by Larvor. Built in 1982, Synthesis 66 offers beautifully ...
Timmerman. Timmerman Yachts is a Russian builder of quality luxury motor yachts. Based in Moscow, it is owned by a group of Dutch and Russian investors and operates out of Moscow Shipyard. Several noted naval architecture and yacht design firms are involved with Timmerman, including Vripack, Guido de Groot Design, Ginton Naval Architects, Jon ...
He is the owner of the Heesen yacht GALVAS.. The GALVAS yacht, built in 2019, is a luxurious creation of Heesen Yachts, boasting an intricate design by H2 Yacht Design.. Powered by robust MTU engines, the yacht cruises comfortably at 12 knots with a maximum speed of 16 knots, offering a range exceeding 3000 nautical miles. The yacht's luxurious interior accommodates 12 guests, and a crew of ...
This design was commissioned by Russian builder Ost Yachts, based in Moscow. Their brief was for a boat with modern stealth-type styling and with potential for multiple usage formats. The version shown here is the first to be introduced and is suitable for use as a sportfisherman, diveboat or patrol boat.
List of Publications. 1. Suzuki T, Wakabayashi C, Tanaka K, Feniouk BA, Yoshida M. (2011): Modulation of Nucleotide Specificity of Thermophilic F O F 1-ATP Synthase by epsilon-Subunit. J Biol Chem. 286, pp.16807-16813. 2. Saita E, Iino R, Suzuki T, Feniouk BA, Kinosita K Jr, Yoshida M. (2010): Activation and stiffness of the inhibited states of F 1-ATPase probed by single-molecule manipulation.